IMPETIGO BULOSA PDF

Pathophysiology[ edit ] This section needs more medical references for verification or relies too heavily on primary sources. Please review the contents of the section and add the appropriate references if you can. Unsourced or poorly sourced material may be challenged and removed. In individuals with healthy skin, there are protein anchors between these two layers that prevent them from moving independently from one another shearing. In people born with EB, the two skin layers lack the protein anchors that hold them together, resulting in extremely fragile skin—even minor mechanical friction like rubbing or pressure or trauma will separate the layers of the skin and form blisters and painful sores.

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Pathophysiology[ edit ] This section needs more medical references for verification or relies too heavily on primary sources. Please review the contents of the section and add the appropriate references if you can. Unsourced or poorly sourced material may be challenged and removed. In individuals with healthy skin, there are protein anchors between these two layers that prevent them from moving independently from one another shearing.

In people born with EB, the two skin layers lack the protein anchors that hold them together, resulting in extremely fragile skin—even minor mechanical friction like rubbing or pressure or trauma will separate the layers of the skin and form blisters and painful sores.

Sufferers of EB have compared the sores with third-degree burns. Furthermore, as a complication of the chronic skin damage, people suffering from EB have an increased risk of malignancies cancers of the skin. Diagnosis[ edit ] Epidermolysis bullosa can be diagnosed either by a skin punch biopsy at the edge of a wound with immunofluorescent mapping, or via blood sample and genetic testing.

Treatment[ edit ] Treatment of the epidermolysis bullosa by transplantation of laminin5 modified stem cells Recent research has focused on changing the mixture of keratins produced in the skin. There are 54 known keratin genes—of which 28 belong to the type I intermediate filament genes and 26 to type II—which work as heterodimers.

If the balance of production could be shifted away from the mutated, dysfunctional keratin gene toward an intact keratin gene, symptoms could be reduced. A clinical trial is planned for 30 subjects. Rather, it is speculated that cross-correction from tissue-resident graft-derived immune cells contributes to the observed clinical benefit.

It has also been designed to evaluate the response to new therapies for the treatment of EB. It was presented at the International Investigative Dermatology congress in Edinburgh in and a paper-based version was published in the Journal of the American Academy of Dermatology in The first two types tended to die in infancy and the last in early adulthood.

The EBRP hosts several annual fundraising events.

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Bullous impetigo on the arm Bullous impetigo Bullous impetigo can appear around the diaper region, axilla , or neck. The bacteria causes a toxin to be produced that reduces cell-to-cell stickiness adhesion , causing for the top layer of skin epidermis , and lower layer of skin dermis to separate. Vesicles rapidly enlarge and form the bullae which is a blister more than 5mm across. Bullae is also known as Staphylococcal scalded skin syndrome.

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Bullous impetigo

Verspreiding: De bacterie verspreid zich snel naar andere kinderen via direct contact. Via rechtstreekse aanraking handen of via speelgoed, kleding of handdoeken raken ook andere kinderen besmet. Adviezen over thuis blijven van school: Vanuit puur epidemiologisch oogpunt is thuis blijven niet nodig omdat de drager al dagenlang voor het ontstaan van de laesies besmettelijk was, verspreiding heeft dan vaak al plaatsgevonden en thuishouden heeft geen effect op het voorkomen van een impetigo-uitbraak. Therapie: Impetigo gaat vanzelf ook over in weken, maar sneller met behandeling. Algemene adviezen: adherente crustae kunnen met zoete olie worden verwijderd, blaardaken kunnen met een washandje of gaas worden verwijderd of losgeknipt. Probeer krabben te voorkomen via krassen kan impetigo uitbreiden. Nagels knippen.

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