ERITROPOETINA HUMANA RECOMBINANTE PDF

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Unitermos Abstract Erythropoietin EPO is a hormone with a very significant activity for the erythroid organic function, responsible for stimulating the production of erythrocytes. Initially the EPO has been used in medicine as an option for treating disorders such as anemia consequent to renal failure or alternative for patients who require frequent blood transfusions. However, the synthetic form of this hormone is also being used for illegal purposes: doping in sports as part of elite competitive athletes.

Erythropoietin provides benefits on oxygenation, as well as it is responsible for the increase in pharmacokinetics potentiality of hemoglobin, leading to a more effective aerobic power, which generates an increase in sports capacity of endurance athletes.

However, concomitant to the benefits, some athletes may experience the adverse effects caused by the indiscriminate use of synthetic erythropoietin, which has become a serious problem in the sports scope. Allied to this, there is a laboratory detection that still has shortcomings and needs improvement, since the different isoforms of synthetic EPO have similar characteristics.

Keywords : Erythropoietin. Recombinant Human Erythropoietin. Sua estrutura pode ser visualizada na figura 1. Figura 1.

Figura 2. Figura 3. Estes dados podem ser observados na tabela Tabela 1. Dados fornecidos pela WADA referentes aos resultados de testes anti-doping realizados no ano de 31 Tabela 2. Dados fornecidos pela WADA referentes aos resultados de testes anti-doping realizados no ano de 31 Tabela 3. Dados fornecidos pela WADA referentes aos resultados de testes anti-doping realizados no ano de 31 Tabela 4.

Dados fornecidos pela WADA referentes aos resultados de testes anti-doping realizados no ano de 31 Tabela 5. Bento, R. Erythropoietin: physico and biochemical analysis. J Chromatogr B ; Adamson JW. Regulation of red blood cell production. Am J Med ;S Erythropoietin abuse in athletes.

Nature ; Schmidt, C. Browne, J. Erythropoietin: gene cloning, protein structure, and biological properties. Gild D. Analytical methods for characterization and quality controlo f Pharmaceutical peptides and proteins, using erythropoetin as na exemple.

Acta Helvetiae. Cheetham, J. NMR structure of human erythropoietin and a comparison with its receptor bound conformation. Nature Structural Bilogy, v. Lasne, F. Detection of recombinant human erythropoietin in urine for doping analysis: Interpretation of isoelectric profiles by discriminant analysis.

Electrophoresis , 28, — Rang H. M, Ritter J. Farmacologia Integrada. Editora Manole Ltda Lacombe, C. Biology of erythropoietin. Haematologica, v.

Baptista, CA et al. Molecular biology of the cell. A global strategy for prevention and detection of blood doping with erythropoietin and related drugs. Effects of erythropoietin on blood pressure.

Kidney Dis. Novel applications of recombinant erythropoetin. Current Opinion in Pharmacology, v. Rio de Janeiro: Roche Halstenson C. Comparative Pharmacokinetics and pharmacodynamics of epoetin alfa and epoetin beta. Pharmacokinetics and pharmacodynamics of darbepoetin alfa and epoetin alfa in patients undergoing dialysis.

Monitoring erythropoietin abuse in athletes. Total fibrin and fibrinogen degradation products in urine: a possible probe to detect illicit users of the physical-performance enhancer erythropoietin? Peptides hormones abuse in sport: state of the art in the detection of growth hormone and erythropoietin.

J Toxicol-Toxin Reviews. In press Marie, E. Analysis of human reticulocyte genes reveals altered erythropoiesis: potential use to detect recombinant human erythropoietin doping. Haematologica ; 89 8 : , August A novel method utilizing markers of altered erythropoiesis for the detection of recombinant human erythropoietin abuse in athletes.

Haematologica ; Kazlauskas R. Sydney Olympics an overview. Recent advances in doping analysis. Recombinant erythropoietin in urine. Joyner MJ et al. Second generation blood tests to detect erythropoietin abuse by athletes: effective but not preventive? Erytropoietin abuse and erytropoietin gene doping. Sports Med. Mol Ther. Artiolli, G. Cazzola, M.

Further concerns about the medical risks of blood doping. Haematologica vol.

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